I play Ultimate Doom, Doom 2, Final Doom, Prince of Persia (the original DOS game by Jordan Mechner), Tomb Raider (the very first game), and Prince of Persia 2: The Shadow and the Flame in my Vista. The 3 Doom games run with my Doom95 engine, while the other POP2 and Tomb Raider in DOSBox. I'm planning to replace the 3 Doom95 engines with DOSBox, since what the Doom95 engine does is let the player skip levels which is a major spoiler for me since I haven't finished any of those games lol (the only DOS game I've finished is Prince of Persia).
In short, DOSBox's the best.